Ovarian cancer cure breakthrough hailed

By Jane Kirby, Press Association Health Editor, in ChicagoPress Association

Researchers have hailed the biggest breakthrough in advanced ovarian cancer for a decade after a new treatment was found to dramatically shrink tumours.

Experts said the results of the early-phase study were “exciting” and “promising” after patients who had exhausted all other treatment options showed an impressive response.

The drug, known as ONX-0801 in the phase 1 clinical trial, was tested in 15 women with advanced ovarian cancer as part of a wider trial run by the Institute of Cancer Research (ICR) and the Royal Marsden NHS Foundation Trust in London.

The aim was to test its safety, but the results were so good that researchers are keen to move the drug to the next stage of research as soon as possible.

In the trial, which is still ongoing, ONX-0801 significantly shrank tumours in seven of the 15 ovarian cancer patients.

In those patients whose tumours had the particular molecular target for the drug, the results were even more impressive, with seven out of 10 women responding.

ONX-0801 is the first in a new class of drugs discovered at the ICR. It attacks ovarian cancer by mimicking folic acid to enter the cancer cells.

The drug then kills these cells by blocking a molecule called thymidylate synthase, thereby causing irreparable DNA damage.

Ovarian cancer cells have an abnormally large number of receptors for folic acid, called alpha folate receptors. This means these cancer cells respond particularly well to the treatment.

Dr Udai Banerji, deputy director of the drug development unit at the ICR and the Royal Marsden, who led the study, said much more research was needed but the results were exciting.

He said: “As this is a completely new mechanism of action it should add upward of six months to patients’ lives with minimal side-effects in extremely late phase ovarian cancer.

“This is much more than anything that has been achieved in the last 10 years.”

He said if clinical trials proved the drug’s effectiveness, it could potentially be used in early-stage disease where “the impact on survival may be better”.

Because the new therapy is so specifically targeted at cancer cells, it leaves healthy cells alone. This means it does not have the side-effects often seen with chemotherapy such as infections, diarrhoea, nerve damage and hair loss.

Experts have also created tests to detect the cells that will respond particularly well to the treatment, meaning doctors can identify those women who will benefit the most.

Dr Banerji said: “The results we have seen in this trial are very promising. It is rare to see such clear evidence of reproducible responses in these early stages of drug development.

“The beauty of this particular drug is that it is targeted to the cancer cell. This means there are fewer side-effects, making it a kinder treatment for ovarian cancer patients.

“It’s early days of course, but I’m keen to see this treatment assessed in later-stage clinical trials as soon as possible.”

Professor Paul Workman, chief executive of the ICR, said: “It’s really exciting to see such positive results in an early-stage trial.

“It looks a highly promising treatment with the potential to have huge benefits for women with ovarian cancer, and I’m very keen to see it progress to later-stage trials.”

The symptoms of ovarian cancer can be vague, and around six out of 10 women are diagnosed at a later stage of the disease.

Around a fifth of women with the cancer are diagnosed at a stage when their disease has already spread around the body and is incurable.

The results of the new trial were presented at the American Society of Clinical Oncology (ASCO) meeting in Chicago.

News Source: http://www.news.com.au/world/breaking-news/ovarian-cancer-cure-breakthrough-hailed/news-story/2160e089b2f84e94314f14af824b0431

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s